TABLE 3.
Equivalent or effective dose per unit injected activity (mSv/MBq) |
Equivalent or effective dose per PET examination (mSv)‡ |
|
---|---|---|
Heart wall | 0.16 | 71 |
Kidneys | 0.09 | 42 |
Liver | 0.12 | 53 |
Red marrow | 0.04 | 17 |
Spleen | 0.10 | 45 |
Whole body | 0.02 | 10 |
| ||
Effective dose | 0.03 | 12 |
Trastuzumab protein dose = 50 mg.
Calculations employed averaged time-activity curves (8 patients) from our 111In-MxDTPA-trastuzumab study (7), which were normalized to averaged blood and organ uptake data from the current 64Cu-DOTA-trastuzumab study (6 patients).
Assumes 64Cu injected activity = 450 MBq, the average in the current study.