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. 2014 Jun 21;11:114. doi: 10.1186/1742-2094-11-114

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Copyright © 2014 Ma et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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IL-1R1 RNAi impairs radial migration of cortical neurons. (A) Schematics of IL-1R1 RNAi procedure. (B) Representative images of coronal sections of P5 rat somatosensory cortex transfected at E16 with different siRNAs constructs using IUE including scramble control, two effective siRNA sequences against IL-1R1 (IL-1R1-i1 and -i2) and IL-1R1 siRNA mixed with human IL-1R1 homologue (IL-1R1-i1 + hIL-1R1, rescue). Sections were counterstained with propidium iodide (red). (C) Histograms showing the percentages of transfected cells at different regions of P5 rat cortex. Numbers in brackets are numbers of brains analyzed in each group. Scale bar, 100 μm. **P <0.01 versus scramble group. E, embryonic day; IUE, in utero electroporation; P, postnatal day.