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. 2014 Jun 21;11:114. doi: 10.1186/1742-2094-11-114

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Copyright © 2014 Ma et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Misorientation of leading processes of migrating neurons by IL-1R1 down-regulation. Representative images of migrating neurons from P5 cortices electroporated at E16 with control (A) or IL-1R1 siRNA (C). The selected regions in the left panels are shown in high magnification at right (B and D, respectively). Arrows and arrow heads in B and D show migrating neurons with normal or reversed leading processes, respectively. Scale bar, 300 μm in A and C, 100 μm in B and D. E, embryonic day; P, postnatal day.