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. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Cancer Res. 2014 Mar 20;74(10):2892–2902. doi: 10.1158/0008-5472.CAN-13-2775

Figure 4.

Figure 4

Disruption of PTK7 in three NSCLC cell lines leads to a decrease cell viability and increase in apoptosis. A. Knock-down of PTK7 with two independent hairpins across a panel of NSCLC cell lines and assessment of cell viability by MTT. B. Scatter plot of PTK7 sensitivity vs copy number in the panel of cell lines. PTK7 sensitivity was calculated by averaging the relative viability across both hairpins after PTK7 knock-down. Copy number at the 6p21 PTK7 locus was queried in the Sanger COSMIC database. R represents the linear correlation coefficient. C. PTK7 knock-down validation by FACS. D. FACS analysis of Annexin-V-positive cells. E. Cleaved poly (ADP-ribose) polymerase (ΔPARP) immunoblotting and β-actin loading control.

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