Table 1.
Patient demographics by KRAS-LCS6 status
| Carrier (N=432) |
wild-type (N=2402) |
Total (N=2834) |
p value | |
|---|---|---|---|---|
| Age, years | 0.391 | |||
| N | 432 (15.2) | 2402 (84.8) | 2834 (100.0) | |
| Median | 58.00 | 58.00 | 58.00 | |
| Range | (22.00–85.00) | (19.00–86.00) | (19.00–86.00) | |
| Age, n (%) | 0.182 | |||
| <50 | 89 (13.6) | 566 (86.4) | 655 (23.1) | |
| >=50 | 343 (15.7) | 1836 (84.3) | 2179 (76.9) | |
| Sex, n (%) | 0.912 | |||
| Female | 201 (15.2) | 1125 (84.8) | 1326 (46.8) | |
| Male | 231 (15.3) | 1277 (84.7) | 1508 (53.2) | |
| Race, n (%) | <0.00012 | |||
| Caucasian | 419 (17.2) | 2021 (82.8) | 2440 (87.5) | |
| Black or African-American | 6 (3.1) | 190 (96.9) | 196 (7.0) | |
| Asian | 1 (0.8) | 131 (99.2) | 132 (4.7) | |
| Other | 0 (0.0) | 22 (100.0) | 22 (0.8) | |
| Missing | 6 | 38 | 44 | |
| Treatment Arms, n (%) | 0.782 | |||
| FOLFOX | 177 (15.1) | 997 (84.9) | 1174 (41.4) | |
| FOLFIRI | 15 (17.2) | 72 (82.8) | 87 (3.1) | |
| FOLFOX × 6 → FOLFIRI × 6 | 12 (12.4) | 85 (87.6) | 97 (3.4) | |
| FOLFOX + C225 | 168 (14.9) | 956 (85.1) | 1124 (39.7) | |
| FOLFIRI+ C225 | 3 (10.0) | 27 (90.0) | 30 (1.1) | |
| FOLFOX × 6 → FOLFIRI × 6 + C225 | 6 (19.4) | 25 (80.6) | 31 (1.1) | |
| Treatment per local physician discretion | 51 (17.5) | 240 (82.5) | 291 (10.3) |
1
Unequal Variance Two Sample T-Test
2
Chi-Squared Test