Table 2.
Patient clinicopathologic characteristics and genetic biomarkers by LCS6 status
| Carrier (N=432) |
Wildtype (N=2402) |
Total (N=2834) |
p value | |
|---|---|---|---|---|
| T stage, n (%) | 0.221 | |||
| T1 or T2 | 75 (17.2) | 361 (82.8) | 436 (15.4) | |
| T3 or T4 | 357 (14.9) | 2040 (85.1) | 2397 (84.6) | |
| Missing | 0 | 1 | 1 | |
| Number of positive LNs, n (%) | 0.241 | |||
| 1–3 | 246 (14.6) | 1440 (85.4) | 1686 (59.5) | |
| >=4 | 186 (16.2) | 962 (83.8) | 1148 (40.5) | |
| Grade, n (%) | 0.941 | |||
| High | 105 (15.2) | 588 (84.8) | 693 (24.5) | |
| Low | 327 (15.3) | 1814 (84.7) | 2141 (75.5) | |
| PS, n (%) | 0.631 | |||
| PS 0 | 335 (15.4) | 1834 (84.6) | 2169 (76.6) | |
| PS 1 or 2 | 97 (14.7) | 564 (85.3) | 661 (23.4) | |
| Missing | 0 | 4 | 4 | |
| Site of disease, n (%) | 0.211 | |||
| Right | 219 (15.5) | 1197 (84.5) | 1416 (50.2) | |
| Left | 208 (15.2) | 1156 (84.8) | 1364 (48.4) | |
| Both | 2 (5.1) | 37 (94.9) | 39 (1.4) | |
| Missing | 3 | 12 | 15 | |
| Site of disease, n(%) | 0.811 | |||
| Missing | 26 | 149 | 175 | |
| Cecum | 93 (16.2%) | 482 (83.8%) | 575 (21.6%) | |
| Ascending colon | 57 (13.7%) | 359 (86.3%) | 416 (15.6%) | |
| Hepatic flexure | 15 (12.9%) | 101 (87.1%) | 116 (4.4%) | |
| Transverse colon | 36 (16.9%) | 177 (83.1%) | 213 (8.0%) | |
| Splenic flexure | 16 (15.1%) | 90 (84.9%) | 106 (4.0%) | |
| Descending colon | 26 (18.1%) | 118 (81.9%) | 144 (5.4%) | |
| Sigmoid colon | 163 (15.0%) | 926 (85.0%) | 1089 (41.0%) | |
| Bowel obstruction, n (%) | 0.771 | |||
| Yes | 72 (15.7) | 387 (84.3) | 459 (16.2) | |
| No | 360 (15.2) | 2015 (84.8) | 2375 (83.8) | |
| Bowel perforation, n (%) | 0.671 | |||
| Yes | 20 (14.0) | 123 (86.0) | 143 (5.0) | |
| No | 412 (15.3) | 2279 (84.7) | 2691 (95.0) | |
| BMI, n (%) | 0.141 | |||
| Under Weight (BMI<20) | 10 (8.5) | 107 (91.5) | 117 (4.1) | |
| Normal Weight (20<=BMI<25) | 114 (15.6) | 617 (84.4) | 731 (25.9) | |
| Over Weight (25<=BMI<30) | 147 (14.6) | 863 (85.4) | 1010 (35.8) | |
| Obese (BMI>=30) | 158 (16.4) | 806 (83.6) | 964 (34.2) | |
| Missing | 3 | 9 | 12 | |
| KRAS, n(%) | 0.881 | |||
| Missing | 13 | 84 | 97 | |
| Mutant | 150 (15.2) | 839 (84.8) | 989 (36.1) | |
| Wildtype | 269 (15.4) | 1479 (84.6) | 1748 (63.9) | |
| BRAF, n(%) | 0.331 | |||
| Missing | 20 | 139 | 159 | |
| Mutant | 58 (17.2) | 279 (82.8) | 337 (12.6) | |
| Wild type | 354 (15.1) | 1984 (84.9) | 2338 (87.4) | |
| MMR, n(%) | 0.681 | |||
| Missing | 12 | 81 | 93 | |
| pMMR | 375 (15.4) | 2056 (84.6) | 2431 (88.7) | |
| dMMR | 45 (14.5) | 265 (85.5) | 310 (11.3) |
1
Chi-Squared Test