Table 3.

Association between the LCS6-variant and DFS stratified by KRAS, BRAF, and MMR status

	HR	95% CI	P-value
KRAS MUTATION STATUS
LCS6 TT, KRAS WT (n=1479)	0.73	0.62 to 0.86	0.002
LCS6 TT, KRAS MUTANT (n=839)	Ref	Ref	Ref
LCS6 GT/GG, KRAS WT (n=269)	0.73	0.55 to 0.96	0.025
LCS6 GT/GG, KRAS MUTANT (n=150)	0.83	0.59 to 1.18	0.304
BRAF MUTATION STATUS
LCS6 TT, BRAF WT (n=1984)	1.18	0.93 to 1.51	0.17
LCS6 TT, BRAF MUTANT (n=279)	1.47	1.08 to 2.00	0.015
LCS6 GT/GG, BRAF WT (n=354)	Ref	Ref	Ref
LCS6 GT/GG, BRAF MUTANT (n=58)	1.81	1.13 to 2.91	0.015
MMR STATUS
LCS6 TT, pMMR (n=2056)	1.09	0.61 to 1.92	0.78
LCS6 TT, dMMR (n=265)	1.13	0.61 to 2.08	0.70
LCS6 GT/GG, pMMR (n=375)	1.03	0.56 to 1.88	0.93
LCS6 GT/GG, dMMR (n=45)	Ref	Ref	Ref