Figure 2. Clinical and Histologic Features of Patients with CARD9 Deficiency.
A skin-biopsy specimen from Patient 13 (Panel A, periodic acid–Schiff) shows irregularly branched septate hyphae (arrowhead) in the center of a granuloma containing multinucleated giant cells (asterisk). Clinical features of Patient 12 (Panel B) and Patient 8 (Panel C) are shown.