. Author manuscript; available in PMC: 2014 Jul 7.

Published in final edited form as: N Engl J Med. 2013 Oct 16;369(18):1704–1714. doi: 10.1056/NEJMoa1208487

Table 2.

Characteristics of the 17 Patients.

Variable	No. of Patients
Male sex	12
Female sex	5
Country of origin
Morocco	2
Algeria	11
Tunisia	4
First symptoms^*
Severe or recurrent tinea capitis	14
Severe or recurrent tinea corporis	10
Onychomycosis	6
Presentations in adulthood
Lymph node enlargement	10
Central nervous system invasion	1
Local organ invasion (bone, diges- tive tract)	2
Associated infection: thrush	6
Deaths^†	5
Dermatophyte identified
T. rubrum	5
T. violaceum	8
Histologic features
Granuloma	10
Necrosis	6
Hyphae on biopsy	12
Biologic exploration^‡
Hypereosinophilia (>500/mm³)	9/10
High IgE levels (>500,000 IU/ml)	4/4
Lymphocyte subset^‡
Normal CD4+ T-lymphocyte subset	4/4
Normal CD8+ T-lymphocyte subset	4/4
Normal B-lymphocyte subset	3/3
Normal NK-lymphocyte subset	3/3

The median age at first symptoms was 8 years (range, 2 to 21).

^†

The median age at death was 34 years (range, 28 to 91).

^‡

For biologic exploration and lymphocyte subset, the number and total number of patients tested are shown for each category.