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. Author manuscript; available in PMC: 2014 Jul 7.
Published in final edited form as: Addict Biol. 2012 Sep 17;19(1):37–48. doi: 10.1111/j.1369-1600.2012.00496.x

Figure 2.

Figure 2

Intravenous cocaine self-administration performance of adult mice exposed to nicotine (n = 7) or vehicle (n = 8) during adolescence. (a)The percentage of active lever presses was substantially and significantly greater (P < 0.05) than inactive lever presses in both nicotine- and vehicle-exposed mice. There was no significant effect of nicotine treatment or cocaine dose. (b) Adolescent nicotine-exposed mice self-administered significantly more cocaine (*P < 0.05) than vehicle-exposed controls at all but the highest cocaine dose. (c) Inter-infusion intervals of nicotine-exposed mice were significantly shorter (*P < 0.05) than those of vehicle-exposed controls at all but the highest cocaine dose