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Least squares mean (±SE) of number of study cigarettes smoked per day for males (Panel A) and females (Panel B). Visit 0 data represent usual brand cigarette use. Triangle represents very low nicotine content (VLNC) cigarette alone; square represents nicotine patch alone; circle represents combination group. An asterisk (*) above a visit indicates a statistically significant difference between the VLNC alone and combination groups for that visit.
