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Least squares mean (±SE) of craving and withdrawal symptoms for males (Panels A and C) and females (Panels B and D) at baseline through week 7. Triangle represents very low nicotine content (VLNC) cigarette alone; square represents nicotine patch alone; circle represents combination group. An asterisk (*) above a visit indicates a statistically significant difference between the VLNC alone and combination groups for that visit.
