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. Author manuscript; available in PMC: 2014 Jul 7.
Published in final edited form as: Nature. 2008 Sep 17;455(7217):1205–1209. doi: 10.1038/nature07284

Figure 2. Sensitivity of MLL-transformed mouse B and myeloid progenitors to GSK3 inhibition.

Figure 2

a, The growth of myeloid progenitors transformed by various oncogenes was assessed after 3 days of culture in the presence or absence of a GSK3 inhibitor. The results of a representative experiment are expressed as the fold change in cell number compared to day 0 (± s.e.m., n = 3). b, c, The morphological features of MLL–ENL transformed myeloid progenitors were assessed after 4 days of culture in the presence or absence of GSK3 inhibitor. Original magnification, ×40. The bar graph (c) indicates the mean number of cells with the indicated morphological features (n = 3). d, The growth of B lymphoid progenitors transformed by E2A–HLF and BCL2 (BiEH)37, TEL–AML1 or MLL–AF4 oncogenes was assessed after 3 days of culture in the absence or presence (5 μM or 10 μM) of SB216763. The results of a representative experiment are expressed as the fold change in cell number compared to day 0 (± s.e.m., n = 3).