Table 3.
KODA-PC–Protein Adducts Identified in KODA-PC-Treated Human Platelets
| SEQUEST score | ||||||
|---|---|---|---|---|---|---|
| protein targets of KODA-PC in platelets |
protein location |
molecule No. (abundance in platelet, ppm)a |
sequences modified | position (adduct type) |
XCorr | ΔM (ppm) |
| CD36 | membrane | 16700 (726) | K*QVVLEEGTIAFK | K40 (SB) | 3.86 | 0.58 |
| talin-1 | cytoplasm | 116000 (5043) | ASVPTIQDQASAMQLSQC*AK | C1023 (MA) | 3.90 | −0.23 |
| helicase SKI2W | cytoplasm | 1000 (43) | ERMQIQK*EMER | K1035 (furan) | 2.94 | −0.89 |
| myosin-13 | cytoplasm | <500 (<22) | ELENELDVEQK*R | K1835 (KA) | 2.12 | 1.08 |
| protein SCAF11 | cytoplasm | NA | SC*NEQIEESEK | C450 (furan) | 2.13 | −5.09 |
| dynein heavy chain 12, axonemal isoform 1 | cytoplasm | NA | C*IIFIDDMNMPALEK | C1955 (MA) | 2.58 | −4.07 |
a
The ppm value was calculated as follows: molecule number of each protein divided by the molecule number of total proteins in one platelet.