Table 3.

Properties of drugs used in pharmacokinetic studies in obese children

Drug	Lipophilicity	Distribution	Protein binding	Elimination
Cefazolin [30]	Low	Widely, to most tissues	80%	Renal (60–80%)
Tobramycin [30]	High	Mainly extracellular fluid	0–30%	Renal (60–85%), mainly excretion, some secretion
Gentamicin [31]	Intermediate	Mainly extracellular fluid	0–30%	Renal (70–100%), mainly excretion, some secretion
Vancomycin [32, 33]	Intermediate	Total body water and other tissues	30–55%	Renal (40–100%)