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. 1999 Jul 15;104(2):189–194. doi: 10.1172/JCI7209

Figure 3.

Figure 3

Immunization with DNA plasmids expressing the insulin B chain, but not the LCMV-NP, is effective in preventing IDDM in RIP-NP mice. RIP-NP transgenic mice were treated with pCMV-NP (protocols 1, 2, or 3; Figure 2), with pCMV-insB (protocol 1; Figure 2), or were fed oral porcine insulin (see Methods). Diabetes was measured weekly by Accucheck (see Methods); the total observation period was 3 months. Group sizes were as follows: 10 mice received pCMV-insB; 10 mice received pCMV-NP; 10 mice received oral porcine insulin (5); 10 mice were untreated controls; 4 mice received pCMV. Definition of diabetes is blood glucose consistently >350 mg/dL. Note that injection of pCMV (protocol 3) did not lower diabetes incidence.