Table 3.
Longitudinal Hazard Ratios for Mortality by Absolute Increase in Composite Physiologic Index and Relative Decrease in Individual Pulmonary Function Tests over 6 and 12 months.
| 6 Month Change n = 211 |
12 Month Change n = 144 |
|||||||
|---|---|---|---|---|---|---|---|---|
| n (%) | HR | 95% CI | p-value | n (%) | HR | 95% CI | p-value | |
| Decline in FEV1 | ||||||||
| 5% | 81 (38) | 1.6 | 1.1–2.3 | 0.018 | 72 (50) | 2.3 | 1.4–3.7 | <0.001 |
| 10% | 44 (21) | 1.6 | 1.0–2.4 | 0.051 | 42 (29) | 2.2 | 1.3–3.5 | 0.002 |
| 15% | 24 (11) | 1.6 | 0.9–2.8 | 0.086 | 25 (17) | 2.1 | 1.3–3.6 | 0.005 |
| 20% | 8 (4) | 1.4 | 0.6–3.5 | 0.473 | 9 (6) | 3.6 | 1.6–8.1 | 0.001 |
| Decline in FVC | ||||||||
| 5% | 88 (42) | 1.8 | 1.2–2.7 | 0.002 | 75 (52) | 1.8 | 1.1–2.9 | 0.012 |
| 10% | 51 (24) | 1.4 | 0.9–2.1 | 0.122 | 51 (35) | 2.4 | 1.5–3.8 | <0.001 |
| 15% | 28 (13) | 1.1 | 0.6–1.8 | 0.857 | 26 (18) | 2.6 | 1.6–4.5 | <0.001 |
| 20% | 12 (6) | 2.0 | 1.0–4.0 | 0.051 | 15 (10) | 3.6 | 1.9–6.9 | <0.001 |
| Decline in DLCO | ||||||||
| 10% | 74 (35) | 1.7 | 1.1–2.5 | 0.011 | 68 (47) | 2.2 | 1.4–3.5 | 0.001 |
| 15% | 51 (24) | 1.6 | 1.1–2.5 | 0.029 | 57 (40) | 2.3 | 1.5–3.7 | <0.001 |
| 20% | 33 (16) | 1.8 | 1.1–3.0 | 0.030 | 37 (26) | 3.0 | 1.8–4.9 | <0.001 |
| 25% | 20 (9) | 2.3 | 1.2–4.2 | 0.010 | 26 (18) | 3.5 | 2.0–6.1 | <0.001 |
| Increase in CPI | ||||||||
| +5 | 51 (24) | 1.7 | 1.1–2.7 | 0.019 | 63 (44) | 2.1 | 1.3–3.5 | 0.004 |
| +10 | 20 (9) | 1.3 | 0.7–2.4 | 0.439 | 21 (15) | 2.3 | 1.2–4.2 | 0.011 |
| +15 | 4 (2) | 2.0 | 0.6–6.6 | 0.240 | 9 (6) | 3.3 | 1.4–7.7 | 0.007 |
| +20 | 2 (1) | 1.2 | 0.2–8.4 | 0.884 | 2 (1) | 5.2 | 1.1–23.8 | 0.036 |
Definition of abbreviations: n = number of patients, HR = hazard ratio, CI = confidence interval, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity, DLCO = diffusing capacity for carbon monoxide, CPI = composite physiologic index.