Table 5.
Longitudinal Hazard Ratios for Mortality Associated with Absolute Increases in Composite Physiologic Index and Relative Decreases in Individual Pulmonary Function Tests over 6 and 12 months in Patients with Combined Pulmonary Fibrosis and Emphysema.
| 6 Month Change | 12 Month Change | |||||||
|---|---|---|---|---|---|---|---|---|
| None to Mild Emphysema | n = 127 | n = 86 | ||||||
| n (%) | HR | 95% CI | p-value | n (%) | HR | 95% CI | p-value | |
| 10% Decline FEV1 | 31 (24.4) | 1.4 | 0.8–2.6 | 0.268 | 26 (30.2) | 2.5 | 1.2–5.1 | 0.012 |
| 10% Decline FVC | 36 (28.3) | 1.4 | 0.8–2.6 | 0.209 | 29 (33.7) | 2.8 | 1.4–5.9 | 0.005 |
| 15% Decline DLCO | 31 (24.4) | 2.4 | 1.3–4.4 | 0.005 | 33 (38.4) | 2.9 | 1.4–5.7 | 0.003 |
| +5 Increase CPI | 33 (26.0) | 2.4 | 1.3–4.4 | 0.003 | 34 (39.5) | 3.6 | 1.7–7.7 | 0.001 |
| Moderate to Severe Emphysema | n = 42 | n = 32 | ||||||
| n (%) | HR | 95% CI | p-value | n (%) | HR | 95% CI | p-value | |
| 10% Decline FEV1 | 4 (9.5) | 8.4 | 1.9–37.8 | 0.006 | 6 (18.8) | 3.7 | 1.0–13.7 | 0.046 |
| 10% Decline FVC | 5 (11.9) | 4.1 | 1.2–14.0 | 0.025 | 9 (28.1) | 2.1 | 0.8–6.0 | 0.154 |
| 15% Decline DLCO | 13 (31.0) | 2.1 | 0.8–5.5 | 0.140 | 12 (37.5) | 2.1 | 0.7–6.0 | 0.174 |
| +5 Increase CPI | 11 (26.2) | 1.9 | 0.6–5.7 | 0.279 | 15 (46.8) | 2.4 | 0.8–7.9 | 0.135 |
Definition of abbreviations: n = number of patients, HR = hazard ratio, CI = confidence interval, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity, DLCO = diffusing capacity for carbon monoxide, CPI = composite physiologic index.