Skip to main content
. Author manuscript; available in PMC: 2014 Jul 7.
Published in final edited form as: Nat Struct Mol Biol. 2013 Dec 8;21(1):36–42. doi: 10.1038/nsmb.2717

Figure 1.

Figure 1

Effects of BAD BH3 stapled peptides on glucokinase (GK) activity. (a) GK activity in the presence of BAD SAHBA (S118D), BAD SAHBA (S118L), or vehicle alone. (b) Activation of GK by BAD SAHBA (S118D) in the presence or absence of the allosteric GK activator (GKA) RO0281675. Vertical lines in (a) and (b) indicate the glucose concentration corresponding to the S0.5 values obtained from the representative experiment shown. Data in (b) show the means and range from a representative experiment, see Table 1 for the summary of all independent experiments performed similarly (n = 3–18 per treatment).