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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Med Chem Res. 2014 Mar 4;23(8):3836–3851. doi: 10.1007/s00044-014-0958-4

Table 4.

Anti-proliferative potential of ITSC analogs

Cell lines INDITSC
IC50 (µM)
 Phenyl ITSC (PEITSC)
IC50 (µM)
 Celecoxib
IC50 (µM)
 Licofelone
IC50 (µM)
 CD44v6shRNA
IC50 (pmoles)
Has2 − + − + − + − + − +
HT29 6.6 ± 7 24.0 ± 2.4 32.0 ± 4.9 52.6 ± 5.1 4.8 ± 1.6 13.5 ± 1.7 72.2 ± 6.9 123.7 ± 10.9 65.5 ± 6 169.6 ± 15
HCA-7 5.0 ± 1.3 28.4 ± 1.9 28.0 ± 3.7 39.7 ± 4.9 3.8 ± 1.3 10.7 ± 1.5 58.9 ± 6.4 115.9 ± 9.5 58.2 ± 5 135.0 ± 11.6
Apc10.1 4.2 ± 1.1 9.8 ± 19 19.5 ± 2.6 37.5 ± 3.3 2.8 ± 0.8 11.5 ± 0.8 41.5 ± 4.8 72.5 ± 7.9 45.8 ± 5.9 75.5 ± 8.9