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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Thorac Oncol. 2014 May;9(5):675–684. doi: 10.1097/JTO.0000000000000148

Table 1.

Univariate Cox Model Analysis for Time to Relapse

Covariate Estimate Stand Error Hazard Ratio HR 95% CI p
Histology: Adenocarcinoma vs Squamous −0.187 0.285 0.830 0.474–1.452 0.513
Gender: Male vs Female 0.153 0.277 1.165 0.676–2.007 0.582
Age 0.026 0.014 1.027 0.999–1.055 0.062
Race: Caucasian vs others 0.544 0.721 1.723 0.419–7.086 0.451
Smoking: Ever vs Never 0.653 0.471 1.922 0.764–4.834 0.165
Smoking: Current vs Never 0.637 0.496 1.890 0.716–4.993 0.199
  Former vs Never 0.668 0.490 1.951 0.746–5.098 0.173
Nodes: N1 vs N0 1.096 0.302 2.991 1.655–5.406 0.0003
No. nodes positive 0.383 0.106 1.467 1.191–1.808 0.0003
Tumor diameter (cm) 0.123 0.058 1.131 1.009–1.267 0.035
Pathologic Stage: II vs I 0.945 0.302 2.573 1.425–4.647 0.002
CAIX, membrane* 0.002 0.001 1.002 0.999–1.004 0.244
CAIX, cytoplasm* 0.002 0.002 1.002 0.999–1.005 0.249
COX2, cytoplasm* 0.001 0.001 1.001 0.998–1.004 0.502
CTR1, cytoplasm* 0.001 0.002 1.001 0.998–1.005 0.436
CTR1, nuclear* 0.000 0.002 1.000 0.997–1.004 0.873
DNMT1, cytoplasm* −0.002 0.002 0.998 0.993–1.002 0.256
DNMT1, nuclear* 0.004 0.004 1.004 0.996–1.012 0.352
DcR2, cytoplasm* 0.004 0.002 1.004 0.999–1.008 0.134
ERCC1, cytoplasm* −0.002 0.002 0.998 0.993–1.002 0.343
ERCC1, nuclear* −0.001 0.002 0.999 0.995–1.002 0.558
HIF1α, cytoplasm* 0.001 0.002 1.001 0.998–1.004 0.544
HIF1α, nuclear* 0.007 0.006 1.007 0.995–1.019 0.245
Rb, cytoplasm* −0.003 0.002 0.997 0.993–1.002 0.224
Rb, nuclear* 0.001 0.002 1.001 0.997–1.004 0.738
SHARP2, cytoplasm* −0.003 0.003 0.997 0.992–1.002 0.219
SHARP2, nuclear* 0.002 0.002 1.002 0.999–1.005 0.262
SURVIVIN, cytoplasm* 0.002 0.002 1.002 0.998–1.005 0.426
SURVIVIN, nuclear* 0.002 0.001 1.002 0.999–1.005 0.24
TGFβ, membrane* −0.004 0.003 0.996 0.991–1.002 0.16
TGFβ, cytoplasm* −0.004 0.002 0.996 0.991–1.000 0.065
VEGF, cytoplasm* −0.002 0.002 0.998 0.994–1.003 0.434
VEGF, nuclear* 0.005 0.008 1.005 0.989–1.021 0.556
p14ARF, cytoplasm* −0.003 0.004 0.997 0.990–1.004 0.431
p14ARF, nuclear* 0.005 0.006 1.005 0.994–1.016 0.385
p16INK4, cytoplasm* −0.002 0.001 0.998 0.996–1.001 0.268
p16INK4, nuclear* −0.001 0.001 0.999 0.997–1.002 0.513
phospho Rb, cytoplasm* 0.000 0.004 1.000 0.991–1.008 0.923
phospho Rb, nuclear* 0.001 0.002 1.001 0.996–1.005 0.751
p21WAF1/CIP1, nuclear* 0.003 0.002 1.003 0.999–1.008 0.109
p53, nuclear* −0.001 0.001 0.999 0.997–1.002 0.491
Ki67, nuclear* 0.002 0.002 1.002 0.998–1.005 0.377
CAIX, membrane, >0 vs 0 0.776 0.323 2.172 1.154–4.090 0.016
CAIX, cytoplasm, >0 vs 0 0.520 0.521 1.681 0.605–4.672 0.319
COX2, cytoplasm, >0 vs 0 0.192 0.474 1.212 0.478–3.072 0.685
CTR1, nuclear, >0 vs 0 0.091 0.313 1.095 0.593–2.022 0.772
DNMT1, cytoplasm, >0 vs 0 −0.200 0.310 0.818 0.446–1.503 0.518
DNMT1, nuclear, >0 vs 0 0.480 0.311 1.617 0.880–2.972 0.122
DcR2, cytoplasm, >0 vs 0 0.393 0.598 1.482 0.459–4.788 0.511
ERCC1, cytoplasm, >0 vs 0 −0.274 0.291 0.760 0.430–1.345 0.346
ERCC1, nuclear, >0 vs 0 −0.367 0.289 0.693 0.393–1.221 0.204
HIF1α, cytoplasm, >0 vs 0 −0.160 0.521 0.852 0.307–2.366 0.759
HIF1α, nuclear, >0 vs 0 0.036 0.341 1.037 0.532–2.021 0.916
Rb, cytoplasm, >0 vs 0 0.468 1.011 1.597 0.220–11.58 0.643
Rb, nuclear, >0 vs 0 0.343 0.368 1.409 0.686–2.896 0.351
SHARP2, cytoplasm, >0 vs 0 0.216 0.723 1.241 0.301–5.123 0.766
SHARP2, nuclear, >0 vs 0 −0.190 0.524 0.827 0.296–2.311 0.717
SURVIVIN, nuclear, >0 vs 0 −0.194 0.722 0.824 0.200–3.391 0.789
TGFβ, membrane, >0 vs 0 0.198 0.285 1.219 0.697–2.130 0.488
TGFβ, cytoplasm, >0 vs 0 −0.038 0.316 0.963 0.519–1.788 0.905
VEGF, nuclear, >0 vs 0 0.138 0.357 1.148 0.571–2.309 0.699
p14ARF, cytoplasm, >0 vs 0 −0.157 0.308 0.854 0.468–1.561 0.609
p14ARF, nuclear, >0 vs 0 −0.133 0.595 0.875 0.273–2.811 0.823
p16INK4, cytoplasm, >0 vs 0 −0.342 0.286 0.711 0.405–1.246 0.233
p16INK4, nuclear, >0 vs 0 −0.335 0.287 0.715 0.408–1.254 0.242
phospho Rb, cytoplasm, >0 vs 0 0.295 0.318 1.343 0.720–2.505 0.354
phospho Rb, nuclear, >0 vs 0 0.002 0.338 1.002 0.517–1.941 0.996
p21WAF1/CIP1, nuclear, >0 vs 0 −0.103 0.474 0.902 0.356–2.286 0.829
p53, nuclear, >0 vs 0 −0.076 0.281 0.927 0.535–1.607 0.787
Ki67, nuclear, >0 vs 0 −0.085 0.522 0.919 0.331–2.555 0.871
*

As a continuous variable.