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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Medchemcomm. 2014 May 14;5(7):949–952. doi: 10.1039/C4MD00162A

Table 1.

Cyclization of the Ugi 4-CR to yield the isoindolone scaffold.

graphic file with name nihms-604271-t0006.jpg graphic file with name nihms-604271-t0007.jpg
entry R(4) n Ugi (%) a entry cyclisation(%) b
5a graphic file with name nihms-604271-t0008.jpg 2 73 6a 55
5b graphic file with name nihms-604271-t0009.jpg 2 50 6b 89
5c graphic file with name nihms-604271-t0010.jpg 2 75 6c 32
5d graphic file with name nihms-604271-t0011.jpg 2 56 6d 72
5e graphic file with name nihms-604271-t0012.jpg 2 40 6e 95
5f graphic file with name nihms-604271-t0013.jpg 3 78 6f 76
5g graphic file with name nihms-604271-t0014.jpg 3 62 6g 42
5h graphic file with name nihms-604271-t0015.jpg 3 43 6h 40
5i graphic file with name nihms-604271-t0016.jpg 3 68 6i 99
5j graphic file with name nihms-604271-t0017.jpg 3 41 6j 79
a

TFA, CH2Cl2, RT. 1 min.

b

NaH, THF, RT, 4h