Table 1.

Cyclization of the Ugi 4-CR to yield the isoindolone scaffold.

entry	R(4)	n	Ugi (%) a	entry	cyclisation(%) b
5a		2	73	6a	55
5b		2	50	6b	89
5c		2	75	6c	32
5d		2	56	6d	72
5e		2	40	6e	95
5f		3	78	6f	76
5g		3	62	6g	42
5h		3	43	6h	40
5i		3	68	6i	99
5j		3	41	6j	79

^aTFA, CH₂Cl₂, RT. 1 min.

^bNaH, THF, RT, 4h