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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: Polym Chem. 2014 May 27;5(13):3977–3981. doi: 10.1039/C4PY00628C

Scheme 1.

Scheme 1

Synthetic route of diblock copolypeptide PBLG30-b-PPLG30 3 via one-pot sequential ROPs of BLG 1 and PLG 2 NCA monomers, followed by post-polymerization modifications to prepare positively-charged diblock copolypeptide 4 or negatively-charged diblock copolypeptide 5 via radical-mediated thiol-yne click-type chemistry with corresponding 2-aminoethanethiol hydrochloride or 3-mercaptopropionic acid, and schematic representation of the further self-assembly of 4 and 5 into micellar cationic 6 and anionic 7 nanoparticles, respectively.