. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Psychiatr Clin North Am. 2013 Oct 6;36(4):497–516. doi: 10.1016/j.psc.2013.08.001

Table 2. Biologic risk factors for late-life depression.

Vascular	General health
Myocardial infarction	Obesity
Coronary heart disease	New medical illness
Hyperhomocysteinemia	Poor health status
Cerebrovascular accident	Poor self-perceived health
Silent cerebral infarction and white matter hyperintensities

Genetic polymorphisms/mutations	Dementia
CADASIL	Alzheimer disease
MTHFR	Vascular dementia
CBS

Diabetes mellitus	Parkinson disease

Abbreviations: CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; CBS, cystathionine beta-synthetase; MTHFR, methyltetrahydrofolate reductase.