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. 2014 Jul 7;9(7):e101951. doi: 10.1371/journal.pone.0101951

Figure 8. Model of r-translocation.

Figure 8

Schematic representation of a model of r-translocation for (a) the ribosome in the PRE and locked states (tRNAs in the pp/E and aa/P states), (b) the ribosome in the PRE and unlocked states just after unlocking (tRNAs in the pp/E and aa/P states), (c) the ribosome in the INT and unlocked states (tRNAs in the ee*/E and pp*/P states) and (d) the ribosome in the POST and relocked states (tRNAs in the ee/E and pp/P states) are shown schematically. The large subunit of the ribosome is not shown for simplicity. (a) and (d) are in the locked and relocked states, respectively (closed state of the P/E-gate). In (a) and (d), the distance between A790 and G1338 of the P/E-gate is so narrow that the P/E-gate blocks the movement of the E-tRNA. (b) and (c) are in the unlocked state (open state of the P/E-gate). In (b) and (c), the distance between A790 and G1338 of the P/E-gate is wide enough to allow the E-tRNA to translocate from the E-stie to P-site.