Table 1. Echocardiographic measurements.

	Male WT	Female WT	Male cs-ERα−/−	Female cs-ERα−/−	Stats
Structural
LVPWId (mm/g)	0.03±0.003	0.04±0.002	0.03±0.006	0.039±0.003	a
LVPWIs (mm/g)	0.05±0.002	0.06±0.003	0.05±0.008	0.061±0.009	a
LVIDId (mm/g)	0.12±0.002	0.15±0.011	0.11±0.008	0.132±0.002	a, b
LVIDIs (mm/g)	0.06±0.005	0.08±0.010	0.006±0.005	0.067±0.003	a, b
IVSd	0.870±0.06	0.890±0.04	0.890±0.1401	0.940±0.064	a
IVSs	1.420±0.15	1.430±0.092	1.450±0.134	1.510±0.256	a
LVM	112.63±20.23	107.65±17.18	95.74±12.60	92.04±6.16
LVMI (mg/g)	3.790±0.45	4.660±0.69	3.250±0.45	3.980±0.09	a, b
Functional
FS (%)	48.68±3.16	47.01±3.47	45.80±2.91	48.88±2.44
E’ (mm/s)	42.41±7.77	36.78±4.78	33.16±5.45	41.08±9.90
A’ (mm/s)	33.16±6.22	N/A	N/A	N/A
S’	34.63±1.44	28.17±3.10	26.84±2.98	28.32±4.10	b, c
IVCT (ms)	5.80±2.05	6.96±2.72	7.78±1.43	7.49±1.74
ET	38.05±3.66	42.11±2.26	38.33±4.18	41.86±3.52
IVRT (ms)	11.52±3.65	10.20±1.61	12.67±2.20	11.57±1.78
Tei Index	0.45±0.09	0.41±0.10	0.53±0.04	0.46±0.08

All dimensional measurements were indexed to body weight. FS, fractional shortening; E, peak velocity of early diastolic trans-mitral flow; A, peak velocity of late (atria) diastolic trans-mitral flow; S’, peak velocity of systolic mitral annular motion; E’, peak velocity of early diastolic mitral annular motion; A’, peak velocity of late (atrial) diastolic mitral annular motion; IVCT, iso-volumic contraction time; ET, LV ejection time; IVRT, iso-volumic relaxation time; Tei Index, LV performance index calculated as (IVCT+IVRT)/ET. Values given as mean ± SD (N = 4/group). N/A, not available; ^adenotes sex significance between male and female mice; ^bdenotes genotypic significance between wild type and cs-ERα^−/− mice; ^cInteraction term of ANOVA analysis was significant; P<0.05 was considered significant.