Skip to main content
. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Nat Rev Microbiol. 2014 Mar 3;12(4):289–299. doi: 10.1038/nrmicro3230

Box 2.

A role for non-conventional T cells in immunity to tuberculosis

Cell Type iNKT cell Group I
CD1-
restricted
T cell		 Mucosal-
associated
invariant T
(MAIT) cell		 γδ T cell Th17 cell
Recognizing CD1d CD1a,
CD1b,
CD1c		 MR1 Butyrophilin142 MHC II
Antigen Type Lipids Lipids Riboflavin
metabolites		 Phosphoantigens Peptides
Required for murine
M. tuberculosis-
immunity? 		No 14, 87, 143, 144 Not found
in mice		 Unknown No No145
Detected in M.
tuberculosis-
infected people? 		Yes 146-148 Yes 149-151 Yes 152, 153 Yes 154 Yes 155
Respond to M.
tuberculosis-
infected
macrophages? 		Yes 156 Yes 149 Yes 157 Yes Yes 158
Stimulation leads to
enhanced
antimycobacterial
function? 		Yes 130, 159
(αGalCer)		 Unknown Unknown Yes 160
(IL-2 +
phosphoantigen)		 Unknown