Table 4. Genotype frequencies with significant differences in the selected SNPs between controls and children with sepsis. a .
| Gene and polymorphic alleles | Control group (n = 100) | Children with sepsis (n = 199) | HWE, χ2 Controls | HWE, χ2 Sepsis | Outcome | ||||
| N | % | N | % | p-value | p-value | OR | 95% CI | p-valueb | |
| IL-1 β-rs1143643 | |||||||||
| C | 52 | 54.7 | 75 | 38.9 | 1 | (reference) | |||
| C/T | 33 | 34.7 | 86 | 44.6 | 1.81 | (1.06–3.09) | 0.03 | ||
| T | 10 | 10.5 | 32 | 16.6 | 0.18 | 0.39 | 2.22 | (1.00–4.90) | 0.05 |
| BPI-rs4358188 | |||||||||
| A | 20 | 20.2 | 40 | 20.1 | 0.70 | (0.34–1.40) | 0.31 | ||
| A/G | 54 | 54.6 | 87 | 43.7 | 0.56 | (0.32–0.99) | 0.05 | ||
| G | 25 | 25.3 | 72 | 36.2 | 0.35 | 0.15 | 1 | (reference) | |
| DEF- β1-rs1799946 | |||||||||
| C | 28 | 29.2 | 79 | 40.3 | 1 | (reference) | |||
| C/T | 49 | 51.0 | 78 | 39.8 | 0.56 | (0.32–0.99) | 0.05 | ||
| T | 19 | 19.8 | 39 | 19.9 | 0.77 | 0.02 | 0.73 | (0.36–1.46) | 0.37 |
| MMP-16-rs2664349 | |||||||||
| A | 49 | 50.0 | 90 | 47.1 | 1 | (reference) | |||
| A/G | 45 | 45.9 | 75 | 39.3 | 0.91 | (0.55–1.51) | 0.71 | ||
| G | 4 | 4.1 | 26 | 13.6 | 0.11 | 0.11 | 3.54 | (1.17–10.72) | 0.03 |
a
The sums may not add up to the total because of some missing values. HWE: Hardy-Weinberg equilibrium.
b
p-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.