Table 5. Genotype frequencies with significant differences in the selected SNPs between controls and children with bacteriologically confirmed (BC) sepsis. a .
| Gene and polymorphic alleles | Control group (n = 100) | Children with BC sepsis (n = 101) | HWE, χ2 Controls | HWE, χ2 BC sepsis | Outcome | ||||
| N | % | N | % | p-value | p-value | OR | 95% CI | p-valueb | |
| DEF- β1-rs1799946 | |||||||||
| C | 28 | 29.2 | 43 | 43.4 | 1 | (reference) | |||
| C/T | 49 | 51.0 | 37 | 37.4 | 0.49 | (0.26–0.93) | 0.03 | ||
| T | 19 | 19.8 | 19 | 19.2 | 0.77 | 0.04 | 0.65 | (0.29–1.44) | 0.29 |
| MMP-16-rs2664349 | |||||||||
| A | 49 | 50.0 | 43 | 44.3 | 1 | (reference) | |||
| A/G | 45 | 45.9 | 40 | 41.2 | 1.01 | (0.56–1.83) | 0.97 | ||
| G | 4 | 4.1 | 14 | 14.4 | 0.11 | 0.35 | 3.99 | (1.22–13.04) | 0.02 |
a
The sums may not add up to the total because of some missing values. HWE: Hardy-Weinberg equilibrium.
b
p-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.