Table 6. Genotype frequencies with significant differences in the selected SNPs between children with non-severe and those with severe sepsis. a .
| Gene and polymorphic alleles | Non-severe sepsis (n = 133) | Severe sepsis (n = 66) | HWE, χ2 Non-severe | HWE, χ2 Severe | Outcome | ||||
| N | % | N | % | p-value | p-value | OR | 95% CI | p-valueb | |
| CD14-rs2569190 | |||||||||
| A | 38 | 30.7 | 14 | 21.9 | 1 | (reference) | |||
| A/G | 63 | 50.8 | 30 | 46.9 | 1.29 | (0.61–2.74) | 0.50 | ||
| G | 23 | 18.6 | 20 | 31.3 | 0.73 | 0.66 | 2.36 | (1.00–5.56) | 0.05 |
| IL8-rs4073 | |||||||||
| A | 28 | 21.7 | 14 | 21.2 | 1.82 | (0.76–4.36) | 0.18 | ||
| A/T | 50 | 38.8 | 38 | 57.6 | 2.77 | (1.34–5.72) | 0.01 | ||
| T | 51 | 39.5 | 14 | 21.2 | 0.02 | 0.22 | 1 | (reference) | |
a
The sums may not add up to the total because of some missing values. HWE: Hardy-Weinberg equilibrium.
b
p-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.