Figure 6. Quercetin in combination with Cisplatin promoted ovarian tumor growth.

Mice were injected with NS, 20/kg Quercetin, 4 mg/kg Cisplatin, or Quercetin plus Cisplatin, ip. C13* cell xenografts (2×10⁶) were inoculated in the right flank of female athymic nude nu/nu mice. Tumor volumes was determined by a caliper and calculated according to the formula (width2×length)/2. (A), Tumor formation in mice of Cisplatin treatment group and combined with Quercetin group. (B), Average relative tumor growth as analyzed by the increase in tumor volumes for 8 mice per experimental group **Cisplatin plus Quercetin VS. Cisplatin, P<0.001; *Quercetin VS. Control, P = 0.015, ANOVA test followed by post hoc pairwise comparisons; (C), Average tumor weights of each group. #Cisplatin combined with Quercetin VS. Cisplatin, P<0.001, ANOVA test followed by post hoc pairwise comparisons; (D), Immunohistochemical analysis of 8-OHdG and SOD1 in xenograft tumors removed from nude mice. (E), The quantification data of the differences in the expression SOD-1 and 8-OHdG, *: P<0.001, **:P<0.001, ANOVA test followed by post hoc pairwise comparisons.