Figure 2. Cartoon of the yeast GK-DNA chimera (in the “open" state) with the DNA spring attached at the sites 60 and 139.

Upon binding of the substrate GMP, the two lobes of the enzyme close on each other. This size conformational motion is a classic example of induced fit. The enzyme structure is PDB 1EX6; the DNA is from the MD simulations of Lankas et al [38], and is kinked in the middle.