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. 1999 Aug 15;104(4):469–481. doi: 10.1172/JCI6067

Figure 1.

Figure 1

R92Q-TnT and truncation-TnT map to 2 distinct functional domains. (a) Exon composition of human cTnT, with positions of disease alleles Arg92Gln and intron 15 G→A marked above. The representative murine transgene allele is in parenthesis below. Tr-Myc represents a loss of exons 15 and 16. Functional domains are depicted by filled bars, with associated protein binding sites below. Location of translational start and stop codons are represented by ATG and TAG, respectively. (b) Constructs used to generate wild-type (WT) and Arg92Gln (R92Q) Myc-tagged murine cardiac TnT.