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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: ACS Nano. 2012 Jul 24;6(8):6776–6785. doi: 10.1021/nn3015008

Figure 1.

Figure 1

Targeted bioconjugate gold nanoparticle design. Gold nanoparticles were modified with a diblock copolymer produced via two-step RAFT polymerization. The polymer's semi-telechelic carboxyl group was conjugated to lysine groups on streptavidin enabling linkage to a biotinylated affinity protein. This universal bioconjugate design allowed facile multiplexed detection by simply mixing different biotinylated antibodies with the sample before addition of the universal streptavidin-gold detection reagent.