Figure 5.
FXYD6 promotes tumor growthin vivo. (A) FXYD6 expression in stable SMMC7721-mock and SMMC7721-FXYD6 cell lines. (B) Mean tumor volumes were measured at indicated time points after mice injection with SMMC7721-mock cells or SMMC7721-FXYD6 cells (n = 6). (C) When tumor size reached to approximately 3 cm3, mice were sacrificed and tumors were excised and the weight was evaluated. (D and E) The proliferation (D) and migration (E) of HepG2 cells were determined in the presence of FD10 or mIgG. (F and G) HepG2 cells were injected subcutaneously into nude mice. After forming tumor, mice were treated with FD10 and mIgG twice a week (n = 5). Tumor volume was calculated (F) and the weight was measured after sacrifice (G). *P < 0.05, **P < 0.01, or ***P < 0.001, compared with the control