Table 1.
List of selected polymorphisms in proteins associated with skin aging
| SNP (rs number) | Protein name | UniProt code | Skin property | SNP variant | SNP effect
|
Reference list number | |
|---|---|---|---|---|---|---|---|
| Expression | Activity | ||||||
| rs1800566 | NAD(P)H dehydrogenase [quinone] 1 | P15559 | Skin antioxidant capacity | C:C T:T |
+1 −1 |
20 | |
| rs1799750 | Matrix metalloproteinase-1 | P03956 | Skin elasticity | -:- G:G |
−1 +1 |
21 | |
| rs4880 | Superoxide dismutase II | P04179 | Skin antioxidant capacity | T:T C:C |
−1 +1 |
22 | |
| rs1141718 | Superoxide dismutase II | P04179 | Skin antioxidant capacity | T:T C:C |
+1 −1 |
23 | |
| rs35652124 | Nuclear factor erythroid 2-related factor 2 | Q16236 | Skin antioxidant capacity | T:T C:C |
−1 +1 |
24 | |
| rs6706649 | Nuclear factor erythroid 2-related factor 2 | Q16236 | Skin antioxidant capacity | C:C T:T |
+1 −1 |
25 | |
| rs6721961 | Nuclear factor erythroid 2-related factor 2 | Q16236 | Skin antioxidant capacity | G:G T:T |
+1 −1 |
26 | |
| rs1050450 | Glutathione peroxidase 1 | P07203 | Skin antioxidant capacity | C:C T:T |
−1 +1 |
27 | |
| rs1001179 | Catalase | P04040 | Skin antioxidant capacity | A:A G:G |
+1 −1 |
28 | |
| rs3025058 | Matrix metalloproteinase-3 | P08254 | Skin elasticity | T:T -:- |
+1 −1 |
29 | |
| rs1800795 | Interleukin-6 | P05231 | Skin elasticity | G:G C:C |
+1 −1 |
30 | |
| rs3918242 | Matrix metalloproteinase-9 | P14780 | Skin elasticity | C:C T:T |
−1 +1 |
31 | |
| rs17553719 | Aquaporin-3 | Q92482 | Skin hydration | A:A G:G |
+1 −1 |
32 | |
Notes: Single nucleotide polymorphism (SNP) effect on protein expression means that the genetic variant leads to a modification in the quantity of protein that is expressed from the gene, and effect on activity means that the genetic variant leads to a modification of the functionality of the protein. UniProt are standard protein codes (www.uniprot.org). The effect of the SNP on protein expression or activity was categorized as +1, which indicates that the SNP increases the protein expression or activity, or −1, which indicates that the SNP decreases protein expression or activity.