Table 1.

Established and novel histopathological markers for the prognostication of patients with colorectal cancer

	Markers of adverse outcome	Markers of favorable outcome	Markers of limited value or still unclear significance
Histopathological variants	Micropapillary adenocarcinoma Signet ring-cell carcinoma Undifferentiated carcinoma	Medullary carcinoma	Mucinous adenocarcinoma
Tumor-growth characteristics and antitumor host response	Poor tumor differentiation Lymphatic invasion Venous invasion Perineural invasion Tumor budding Tumor necrosis	Inflammation at the invasive tumor margin (Klintrup score) Antitumor immune response (Ogino score) Tumor-associated eosinophils	Tumor-associated macrophages