Figure 1.

Sections of nasal and laryngeal cartilage from female LEW.1F rats. (a and b) Nasal septum from rats immunized with CMP. (a) Tissue taken at day 18 after immunization. Erosion of the nasal septal cartilage caused by inflammatory cells is seen. (b) Tissues taken in chronic phase, 120 days after immunization. Shown are irregular tissue and new formation of cartilage, i.e., new irregular cartilage tissue outside the original and normal cartilaginous structures. (c and d) Laryngeal tissue from rats immunized with CMP. (c) Tissue taken day 18 after immunization. A massive invasion of inflammatory cells is seen causing cartilage erosion. (d) Tissues taken in chronic phase, 120 days after immunization. Irregular tissue, new formation of cartilage, and a small area of inflammatory cells are seen. (a–d) Hematoxylin and erythrosin staining. (e and f) Staining with CMP-specific polyclonal antibodies. Tissue from a normal female LEW.1F rat showing positive staining in larynx (e) but not in the ear (f). (a–f) Original magnification: ×200.