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. 1999 Sep 1;104(5):647–656. doi: 10.1172/JCI6670

Figure 8.

Figure 8

Spatial memory performance using an MWM paradigm in mice. Mean latencies (± SEM) to find a submerged (hidden) platform on days 14–18 after TBI. Uninjured iNOS+/+ (open squares) and iNOS–/– (filled squares) mice performed equally well on this task, as assessed for 5 days. After injury, both iNOS+/+ (open circles) and iNOS–/– (filled circles) mice showed impaired performance, as assessed for 5 days (vs. either uninjured group). After TBI, iNOS–/– mice showed markedly impaired performance (*P < 0.05 vs. injured iNOS+/+ mice on days 15 and 18). Improved performance on visible-platform testing (days 19–20) indicates that the deficits seen were not due to visual impairment.