Figure 6.
The effect of HOE 694 on the recovery of WT and mutant CA1 neurons from acid load. (a) In an NH4Cl prepulse experiment on a WT neuron, 100 μM HOE 694 was applied after the first acidification. This graph shows an apparently smaller slope during the application of HOE 694 in the first recovery than in the second one. (b) Summary of the double acid-loading experiments on WT (n = 4) and mutant neurons (n = 4). Paired comparison analysis showed that 100 μM HOE 694 can significantly reduce the H+ flux rate in WT neurons but not in NHE1 mutant neurons. *P < 0.05.