Table 2.
Biochemical features of granulomatous hypophysitis
| Endocrine axis | Number of reports assessing axis (%) | Number of reports where data was available (%) | ||
|---|---|---|---|---|
| Axis supressed | Axis normal | Axis elevated | ||
| Growth hormone (GH or IGF-1) | 30/82 (36.6) | 20/30 (66.7) | 9/30 (30.0) | 1/30 (3.3) |
| HPA (ACTH or cortisol) | 52/82 (63.4) | 38/52 (73.1) | 14/52 (26.9) | 0 (0) |
| Gonadal (FSH or LH) | ||||
| Males | 14/23 (60.9) | 10/14 (71.4) | 4/14 (28.6) | 0 (0) |
| Females | 39/59 (66.1) | 25/39 (64.1) | 14/39 (35.9) | 0 (0) |
| Combined | 53/82 (64.6) | 35/53 (66.0) | 18/53 (34.0) | 0 (0) |
| Thyroid (TSH or T4) | 54/82 (65.9) | 35/54 (64.8) | 19/54 (35.2) | 0 (0) |
| Prolactin | 54/82 (65.9) | 7/54 (13.0) | 19/54 (35.2) | 28/54 (51.9) |
| Other endocrine abnormalities | Number of cases (%) | |||
| Laboratory diagnosis of diabetes insipidus reported | 22/82 (26.8) | |||
| Panhypopituatirism | 40/82 (48.8) | |||
GH growth hormone, IGF-1 insulin-like growth factor 1, HPA hypothalamic–pituitary–adrenal, ACTH adrenocorticotropic hormone, FSH follicle stimulating hormone, LH lutenising hormone, TSH thyroid stimulating hormone, T4 thyroxine