Figure 5.

SOX2 and SKI display partly redundant roles in squamous cell carcinogenesis. (a) Western blot analysis of SOX2-transduced primary fibroblasts (MEFs), LSL KrasG12D p53^KO lung epithelial cells (LECs) and clonal KrasG12D p53^KO cells. SCC cell line #7 is shown as control. (b) The histology of tumors derived from vector-transduced (left) or SOX2-transduced (right) KrasG12D p53^KO cells or ADC#6 cell line. (c) SOX2 and SKI display reciprocal and partly redundant roles in the regulation of plasticity and lineage commitment of lung cancer cells. Note that SP cells are predisposed to the development of ADC, whereas TP cells are predisposed to the development of SCC