Figure 6.

Identification of a KrasG12Di expression signature in lung cancer cells. (a) Schematic of the experimental approach for microarray analysis of untransformed (1B), premalignant (2B) and tumor-derived KrasG12D p53^KO cells (3B–6B). Primary ADC#6 (3B) was used to derive the corresponding secondary tumors (4B and 6B). (b) Heat maps showing differentially expressed genes compared with untransformed controls (1B). Genes with four-fold or greater difference are shown. (c) The number of differentially expressed genes in premalignant KrasG12D p53^KO cells (green), ADC (orange) and SCC (blue) is shown. (d) Activity of gene regulatory modules in untransformed, premalignant and tumor-derived KrasG12D p53^KO cells