Table 1.
Genomic loci implicated in Parkinson’s disease by genome-wide association analyses
| Gene | Chr |
Associated SNP/locus |
Genes within locus a |
Odds ratio [95% CI] |
P -value |
|---|---|---|---|---|---|
|
GBA |
1q21 |
N370S |
TRIM46, MUC1, MIR92B, THBS3, GBAP1-GBA-FAM189B, SCAMP3, CLK2, HCN3, PKLR |
3.37 [2.67-4.29] |
1.11E-24 |
|
SYT11/RAB25 |
1q21 |
chr1:154105678 |
MIR7851, UBQLN4, LAMTOR2-RAB25-MEX3A, LMNA |
1.67 [1.41-1.98] |
5.70E-09 |
|
PM20D1 |
1q32 |
rs11240572 |
NUCK1-RAB7L1-SLC41A1, PM20D1 |
0.74 [0.69-0.80] |
1.01E-14 |
|
STK39 |
2q24 |
rs2102808 |
STK39 |
1.28 [1.19-1.38] |
1.54E-11 |
|
MCCC1/LAMP3 |
3q27 |
rs11711441 |
MCCC1-LAMP3-MCF2L2 |
0.84 [0.80-0.89] |
8.72E-12 |
|
BST1 |
4p15 |
rs4698412 |
FAM200B-BST1 |
0.87 [0.83-0.91] |
2.28E-10 |
|
GAK/DGKQ |
4p16 |
rs1564282 |
CPLX1-GAK-TMEM175-DGKQ-SLC26A1, IDUA, FGFRL1 |
1.29 [1.20-1.38] |
6.54E-13 |
|
SNCA |
4q21 |
rs356220 |
SNCA-MMRN1 |
1.30 [1.25-1.34] |
3.06E-49 |
|
HLA-DRB5 |
6p21 |
rs2395163 |
HLA-DRB5-HLA-DRB1, HLA-DRB6 |
0.75 [0.68-0.84] |
2.90E-07 |
|
GPNMB |
7p15 |
rs156429 |
GPNMB-MALSU1-IGF2BP3 |
0.89 [0.86-0.93] |
2.69E-10 |
|
LRRK2 |
12q12 |
rs34778348 |
SLC2A13-LRRK2-MUC19, CNTN1 |
2.23 [1.89-2.63] |
2.97E-21 |
|
CCDC62/HIP1R |
12q24 |
rs12817488 |
DENR-HIP1R-VPS37B, ABCB9, OGFOD2, |
1.17 [1.09-1.25] |
2.99E-06 |
| MAPT/STH | 17q21 | H1H2, 900kb inversion | ARHGAP27, PLEKHM1, CRHR1, SPPL2C-MAPT-STH, KANSL1, LRRC37A, NSFP1, ARL17A/B | 0.78 [0.75-0.80] |
3.54E-52 |
Chr, chromosomal band; CI, confidence interval. aGenes within 100 kb of the most significantly associated SNP annotated from the UCSC genome browser (hg19). Odds ratios and P-values are the most significant findings from the PDGene database [150].