. Author manuscript; available in PMC: 2014 Jul 8.

Published in final edited form as: Nat Rev Cancer. 2010 Sep 3;10(10):683–695. doi: 10.1038/nrc2899

Table 2.

Mouse models of Hedgehog and β-catenin deregulation in the pancreas

Genetic model	Phenotype	Refs
*Hedgehog*
Pdx1-Shh	Atrophic pancreas displaying lesions reminiscent of PanIN1 and 2 embedded in intestinal-like stroma	57
Pdx1-Cre;CLEG2	Development of large, undifferentiated pancreatic tumours	85
Pdx1-Cre;CLEG2;LSL-Kras^G12D	Accelerated PanIN development and undifferentiated ‘CLEG2-like’ tumours	85
CAGGS-CreER;R26-SmoM2	Development of MCN-like lesions	130
p48-Cre;LSL-Kras^G12D; Trp53^flox/+;Smo^flox/flox	No difference in PanIN and PDAC development compared to p48-Cre; LSL-Kras^G12D;Trp53^flox/+ mice	81
p48-Cre;LSL-Kras^G12D; SmoM2	No acceleration of PanIN development compared to p48-Cre;LSL-Kras^G12D mice	63
β-catenin
Pdx1-Cre^Late; Ctnnb1^exon3/+	Acinar proliferation and postnatal pancreatomegaly. No tumour development	102
Pdx1-Cre;Apc^flox/flox	Acinar proliferation and postnatal pancreatomegaly. No tumour development	103
p48-Cre;Ctnnb1^exon3/+	Development of tumours resembling human solid pseudopapillary tumour	104
p48-Cre;Ctnnb1^exon3/+; LSL-Kras^G12D	Development of tumours resembling human intraductal tubular tumour	104

Apc, adenomatous polyposis coli; Ctnnb1, β-catenin; MCN, mucinous cystic neoplasm; PanIN, pancreatic intraepithelial neoplasia; PDAC, pancreatic ductal adenocarcinoma; Shh, sonic hedgehog; Smo, smoothened.