Table 1.
Thrombin-antithrombin (TAT) complex levels in wild-type, endothelial cell protein C receptor (EPCR)-overexpressing and EPCR-deficient mice before and after administration of FVIIa (120 μg kg–1 body weight); blood was drawn prior to FVIIa administration and 1 h after FVIIa administration (n = 10 mice per group)
Genotype | TAT complex levels (ng mL –1) | |
---|---|---|
Before FVIIa | After FVIIa | |
Wild type | 11.5 ± 0.56 | 13.7 ± 1.42 |
EPCR-overexpressing | 11.8 ± 1.10 | 13.2 ± 1.16 |
EPCR-deficient | 11.6 ± 0.37 | 12.7 ± 0.82 |