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. 2014 Jun 19;3(2):426–451. doi: 10.3390/biology3020426

Figure 4.

Figure 4

Association of hypermethylated myogenic DMRs with boundaries of active promoter-like chromatin in TBX15 and further upstream. (a) The underlined ENSEMBL isoform is the one that the RNA-seq data supports for Mb and Skin fibroblast 2 (foreskin fibroblasts; Figure 3). MbMt-hypermethylated DMRs (red) and one hypomethylated DMR (green) are indicated. The hypermethylated DMRs or clusters of DMRs are numbered for reference in the text. (b) Chromatin state segmentation analysis as in Figure 2. (c) DNaseI hypersensitivity signal (ENCODE/Open chromatin by DNaseI HS/Duke University [17,32]). (d) Examples of RRBS data tracks for the indicated samples as in Figure 3 but for a larger region (chr1:119501896-119558791). The dotted box at the bottom shows a region previously studied for DNA methylation in placenta by Chelbi et al. [55], as described in the text.