Table 2.

Significant Findings from the Combined Metaregression of Stage 1 and Stage 2 Subgroups

SNP ID	Chr	Position (in basepairs)	Genomic Location	Primary Trait	Other Trait(s)	NS	N	Ref Freq	Ref All	p Value Main-Effects-Only Model	Metaregression Model with SNP Main Effect and Age Interaction (2 df)
											β0	se(β0)	β1	se(β1)	p Value of Interaction	p Value of 2 df Test
At Least Nominal Evidence (p < 0.05) of Interactions
rs880315	1	10,719,453	intron CASZ1	SBP	MAP	56	74,498	0.64	T	2.35 × 10−7	0.861	0.353	−0.026	0.007	1.52 × 10−4	1.21 × 10−9∗
rs6797587	3	48,172,618	near 3′ CDC25A	MAP	DBPa	87	99,189	0.68	G	4.69 × 10−11∗	0.748	0.202	−0.008	0.004	0.04	4.36 × 10−11∗
rs11099098	4	81,388,936	intergenic (PRDM8-FGF5)	SBP	MAP	81	96,217	0.29	T	2.85 × 10−13∗	−0.199	0.335	0.016	0.007	0.02	1.56 × 10−13∗
rs198846	6	26,215,442	downstream HIST1H1T	DBP	MAPa	87	99,207	0.84	G	1.78 × 10−13∗	0.088	0.250	−0.011	0.005	0.03	1.48 × 10−13∗
rs12705390	7	106,198,013	intergenic (CCDC71L-PIK3CG)	PP		87	99,094	0.78	G	1.08 × 10−12∗	0.281	0.264	−0.014	0.005	0.006	2.42 × 10−13∗
rs7070797	10	63,221,779	intergenic (C10orf107-ARID5B)	MAP	SBP, DBPa	87	99,189	0.84	G	6.31 × 10−19∗	0.014	0.282	0.012	0.006	0.02	5.62 × 10−19∗
rs4601790	11	65,110,482	intron EHBP1L1	MAP	DBP	87	99,188	0.27	G	0.001	0.909	0.220	−0.022	0.004	2.90 × 10−7	9.93 × 10−9∗
rs11072518	15	73,021,663	upstream COX5A	MAP	SBP, DBP	87	99,189	0.36	T	3.91 × 10−21∗	0.973	0.192	−0.010	0.004	0.006	1.11 × 10−21∗
rs17608766	17	42,368,270	intron or UTR 3′ of GOSR2	PP		86	97,437	0.84	T	5.62 × 10−9∗	0.524	0.322	−0.019	0.006	0.003	4.49 × 10−10∗
Joint Test Driven by Main Effects Only
rs7537765	1	11,809,890	intron CLCN6	MAP	SBPa, DBP	87	99,181	0.16	G	1.66 × 10−19∗	−0.957	0.249	0.008	0.005	0.12	5.58 × 10−19∗
rs6707357	2	164,722,539	intergenic (FIGN-GRB14)	SBP		87	99,177	0.45	T	1.49 × 10−11∗	−0.634	0.268	0.004	0.005	0.50	1.03 × 10−10∗
rs7733138	5	157,807,971	intergenic (nearest gene EBF1)	MAP	DBPa	87	99,189	0.39	T	6.01 × 10−13∗	0.006	0.194	−0.007	0.004	0.05	8.75 × 10−13∗
rs4841569	8	11,489,586	intergenic (BLK-GATA4)	SBP	MAP	82	97,928	0.57	G	5.56 × 10−10∗	0.140	0.311	0.008	0.006	0.21	2.03 × 10−9∗
rs1813353	10	18,747,454	intron CACNB2	MAP	SBP, DBP	87	99,189	0.68	T	1.29 × 10−17∗	0.564	0.202	−0.003	0.004	0.52	1.13 × 10−16∗
rs11191454	10	104,649,994	intron AS3MT	SBP		84	97,234	0.08	G	6.50 × 10−12∗	−0.320	0.484	−0.011	0.010	0.25	2.98 × 10−11∗
rs1801253	10	115,795,046	missense ADRB1	MAP	SBPa, DBP	82	97,928	0.27	G	7.71 × 10−14∗	−0.336	0.215	−0.002	0.004	0.71	6.86 × 10−13∗
rs381815	11	16,858,844	intron PLEKHA7	MAP		87	99,189	0.25	T	3.31 × 10−9∗	0.028	0.217	0.006	0.004	0.16	9.26 × 10−9∗
rs2681472	12	88,533,090	intron ATP2B1	SBP	DBPa, MAP	87	99,177	0.17	G	4.59 × 10−23∗	−0.483	0.348	−0.008	0.007	0.24	2.84 × 10−22∗
rs3184504	12	110,368,991	missense SH2B3	MAP	SBP, DBPa	87	99,187	0.48	T	1.17 × 10−21∗	0.325	0.186	0.003	0.004	0.47	1.09 × 10−20∗
rs260014	20	57,192,854	upstream ZNF831	MAP	SBPa, DBP	82	97,941	0.85	T	1.50 × 10−11∗	−0.302	0.284	−0.004	0.006	0.49	1.02 × 10−10∗

Abbreviations are as follows: Chr., chromosome; N_S, number of study and age bin subgroups included in the analysis; N, number of participants represented by the analysis; Ref Freq, frequency of the coded allele; Ref All, the coded allele; se, standard error; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure. The primary trait had the minimum p value for the joint 2 df test of the index SNP in that locus. The other traits column indicates nonprimary traits significantly associated with SNPs in this locus.

^aThe index SNP for this trait differed from the index SNP for the primary trait (see Tables S8, S9, S10, S11, and S12). The p value main effect test was derived from the model containing only the SNP main effect (i.e., test that the intercept is zero). For the model containing the SNP main effect and age interaction, β₀ is the theoretical SNP effect on blood pressure (in mmHg) at birth (age = 0) and β₁ is the change in the SNP effect on blood pressure (in mmHg) per 1 year increase in age; the estimated SNP effect at a particular age was the addition of the intercept and the product of that age and the coefficient for age. Asterisks (^∗) indicate values that achieve genome-wide significance.