. 2014 Jul 3;95(1):24–38. doi: 10.1016/j.ajhg.2014.05.010

Table 3.

Selected Significant and Suggestive Findings from the Within-Age-Bin Meta-analysis of Stage 1 Subgroups

Age Bin	rs Number (NCBI 36)	Chr.	Position	Genomic Location	Ref Allele	Trait	No. Studies	N	All Freq	β (in mmHg)	se (β)	λ	p Value	Direction of Effects
20–29	rs16833934	3	165,219,944	intergenic near MIR1263	G	DBP	2	2,242	0.26	−1.63	0.29	1.00	1.39 × 10⁻⁸^∗	- -
	rs16833934	3	165,219,944	intergenic near MIR1263	G	MAP	2	2,241	0.26	−1.33	0.27	1.02	7.12 × 10⁻⁷	- -
	rs12195230	6	97,606,768	intron KLHL32	G	SBP	2	2,246	0.75	1.79	0.35	1.01	4.60 × 10⁻⁷	++
	rs12195036	6	166,371,687	near LINC00602	T	MAP	2	2,241	0.95	−3.11	0.61	1.02	5.04 × 10⁻⁷	- -
	rs2702888	8	6,752,442	DEFB1-DEFA6	G	PP	2	2,242	0.65	−1.36	0.27	1.00	3.87 × 10⁻⁷	- -
	rs2196122	11	4,842,124	OR51H1P-OR51H2P	G	SBP	2	2,246	0.84	1.91	0.38	1.01	7.20 × 10⁻⁷	++
	rs10143078	14	69,951,242	intron SYNJ2BP	C	SBP	2	2,246	0.04	−4.06	0.81	1.01	5.93 × 10⁻⁷	- -
40–49	rs825937	2	4,785,902	near LINC01249	C	PP	5	13,810	0.83	0.83	0.16	1.01	2.32 × 10⁻⁷	+++++
40–49	rs11816631	10	99,552,562	SFRP5-GOLGA7B	G	PP	3	9,946	0.06	1.99	0.39	1.01	2.95 × 10⁻⁷	+++
50–59	rs3118867	9	89,451,515	intron DAPK1	G	DBP	7	21,033	0.47	−0.49	0.09	1.05	3.87 × 10⁻⁷	- - - - - - -
50–59						MAP	7	21,035	0.47	−0.55	0.11	1.04	4.12 × 10⁻⁷	- - - - - - -
60–69	rs4638749	2	108,250,474	downstream SULT1C3	G	DBP	8	12,082	0.76	−0.81	0.16	1.03	6.13 × 10⁻⁷	+- - - - - - -
	rs4841895	9	136,563,863	RXRA-COL5A1	G	MAP	8	12,082	0.65	0.81	0.16	1.02	7.62 × 10⁻⁷	++++++++
	rs747685	17	721,801	intron NXN	T	MAP	8	12,082	0.86	1.50	0.30	1.02	6.32 × 10⁻⁷	++++++++
	rs747687	17	722,084	intron NXN	G	DBP	8	12,082	0.86	1.37	0.26	1.03	1.50 × 10⁻⁷	++++++++
70–79	rs603788	10	78,881,268	intron KCNMA1	G	DBP	4	3,014	0.50	1.73	0.35	1.00	9.37 × 10⁻⁷	++++
70–79						MAP	4	3,014	0.50	2.08	0.42	1.01	8.84 × 10⁻⁷	++++

Abbreviations are as follows: Chr, chromosome; Ref Allele, coded allele; N, number of participants meta-analyzed in the age bin; All Freq, coded allele frequency; β, effect of each copy of the coded allele on blood pressure; se(β), standard error of the β; λ, genomic inflation factor in that age bin. Age bins 1 through 6 comprised individuals 20 to 29 years old and subsequently in 10 year increments. Asterisk (^∗) indicates value achieves the p ≤ 5 × 10⁻⁸ threshold for significance.