Table 1.
Summary of Discovery Cohorts, Sample Sizes, and Visits for the LTA Analyses
| Cohort | No. of Visits | No. of Individuals | Age at First Visit in Years (SD) | Age at Last Visit in Years (SD) | Mean BMI in kg/m2(SD) | Mean SBP in mmHg (SD) | Mean DBP in mmHg (SD) | Antihypertensive Therapy at First Visit | Antihypertensive Therapy at Last Visit |
|---|---|---|---|---|---|---|---|---|---|
| AGES Reykjavik Study | 2 | 526 | 66.0 (7.0) | 78.5 (5.9) | 26.2 (3.9) | 141.4 (18.8) | 82.1 (8.7) | 24% | 65% |
| ARIC Study | 4 | 7,310 | 54.3 (5.7) | 63.1 (5.6) | 27.0 (4.9) | 118.5 (17.0) | 71.7 (10.0) | 26% | 40% |
| CARDIA | 4 | 1,671 | 32.6 (3.3) | 45.8 (3.4) | 25.6 (5.1) | 106.3 (11.4) | 67.8 (9.5) | 0.9% | 11% |
| CHS | 4 | 3,159 | 72.4 (5.4) | 75.3 (5.4) | 26.3 (4.5) | 138.7 (22.5) | 72.2 (11.9) | 35% | 41% |
| FHS original cohort | 4 | 660 | 74.4 (4.5) | 85.6 (4.0) | 26.7 (4.6) | 148.1 (23.5) | 72.9 (11.3) | 49% | 60% |
| FHS offspring | 4 | 3,235 | 50.7 (9.8) | 61.0 (9.5) | 26.8 (4.9) | 127.4 (20.0) | 79.7 (10.6) | 15% | 32% |
| MESA | 4 | 2,414 | 62.7 (10.2) | 66.9 (10.2) | 27.7 (5.1) | 123.5 (20.5) | 70.1 (9.9) | 33% | 45% |
| RS 1 | 4 | 4,710 | 67.9 (8.2) | 75.5 (6.2) | 26.3 (3.6) | 140.4 (22.8) | 74.9 (11.7) | 22% | 37% |
| RS 2 | 4 | 1,535 | 63.7 (2.3) | 67.9 (7.2) | 27.2 (4.1) | 143.4 (21.6) | 79.7 (11.1) | 21% | 30% |
| WGHS | 3 | 21,409 | 54.7 (7.0) | 65.2 (6.8) | 25.9 (4.9) | 124.8 (15.4) | 77.3 (9.7) | 13% | 43% |
Abbreviations are as follows: AGES, Age, Gene/Environment Susceptibility; ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; CARDIA, Coronary Artery Risk Development in Young Adults; CHS, Cardiovascular Health Study; DBP, diastolic blood pressure; FHS, Framingham Heart Study; MESA, Multi-Ethnic Study of Atherosclerosis; RS, Rotterdam Study; SBP, systolic blood pressure; and WGHS, Women’s Genome Health Study.